Yes, you can. The spirit you choose mainly affects smoothness and flavor intensity. When you are Making Limoncello, vodka is actually the more traditional choice, since it is neutral and lets the lemon zest release its flavor. It doesn’t add any competing notes, so the bright, fragrant oils from the lemon zest stand out clearly, giving you that classic smooth and citrus-forward taste Italians are known for.
Gin, on the other hand, will add its own twist to your mix. Because it’s made with botanicals like juniper, coriander, or citrus peel, those flavors mix in with the lemon and give you something more layered. Some people love that herbal, slightly spiced edge, while others feel it takes away the clean, lemony kick you will get in the traditional version.
The best way to decide is to experiment in small bottles. Try one bottle with vodka for the crisp, classic version, and another with gin for a more adventurous, aromatic take. Either way, the process stays the same, but the flavor changes. That way, you can see which style actually matches your taste.